Detail Cantuman Kembali
Studi Regimentasi Dosis Insulin Pada Pasien Diabetes Mellitus Tipe 2 (Penelitian Dilakukan Di Rumkital Dr. Ramelan Surabaya)
- Bagikan:
This study was carried out to describe the dose regimentation of insulin in patients with type 2 diabetes mellitus (DM2) hospitalized in Dr. Ramelan Navy Hospital Surabaya during the period of January 1st to December 31' 2008 with complete medical record. The purposes of this study were to analyze the use of insulin for decreasing the blood glucose level, the effectivity of insulin and several problems using insulin in patient with type 2 in term of dose, route of administrations, any potential interactions. Analyzis was carried out using laboratory and clinical data. The research method was regression and correlation analysis. The data collected by simple random sampling. From 1,111 samples of patients' medical records, 120 samples were taken but only 100 samples met the inclusion criteria.
Based on regression and correlation analysis, there was four correlations between insulin and blood glucose level. First, the correlation between insulin dose versus decrease of blood glucose level in patient with type 2 DM (Y = 2.602X + 60.04 and R2 = 0.207 ; F(12,14) = 3.862 and p = 0.009). Second, correlation between insulin dose IV versus decrease of blood glucose in patient type 2 DM (Y = 6.910X + 3.102 and R2 = 0.754 ; F(5,2) = 199.48 and p = 0.005). Third, correlation between insulin dose SC versus decrease of blood glucose in patient with type 2 (Y = 0.811X + 92.02 and R2 = 0.034 ; Fo0,8 = 2.606 and p = 0.094). The last, correlation between interval of using short acting insulin versus decrease of blood glucose in patient with type 2 DM (Y = -7.27X + 188.0 and R2 = 0.176 ; F(2,21) = 2.798 and p = 0.084).
Dose regimentation of insulin with type 2 diabetes mellitus following acute hyperglycemia is regulated using rapid intravenous insulin to decrease blood glucose level about 50-75 mg/dl per hour. Insulin is then continued to subcutaneous administration when the blood glucose level reach 200 mg/dl. There was inter individual variability for the effectiveness of insulin as increasing dose of insulin was not associated with decreasing patient's blood glucose level. Intravenous dose of insulin almost closely related to the increasing dose of insulin than subcutaneous administration. Likewise, there was insignificant decrease of blood glucose level for the use of short acting insulin if this drug was given at long interval between one dose to the other.
Novita, Rennie Puspa - Personal Name
6B.S Ren s
6B.S Ren s
Text
Indonesia
Fakultas Farmasi UNAIR
2009
Surabaya
xvi; 75p.; 29,5cm
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